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Their capacity to penetrate biological barriers, including the bloodbrain barrier and intestinal barrier, allows them to accumulate in brain tissue, inducing a spectrum of neurotoxic effects, including neuroinflammation, oxidative stress, mitochondrial dysfunction, disruption of neurotransmitter systems- that are closely associated with the development of neurodegenerative diseases (e.g., Parkinsons disease, Alzheimers disease, amyotrophic lateral sclerosis, ischemic stroke) and psychiatric conditions (e.g., depression, anxiety, schizophrenia, bipolar disorder)

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