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Indeed, aldolase-deficient cells displayed an increased protrusive area compared to control cells or cells depleted of GAPDH or PFK (Fig
The protective effect of UA in parkinsonian model systems is also found to be dependent on Glut9-mediated transport, which is upregulated by UA in dopaminergic neurons in vitro 38
183 This hypothesis is supported by the lower activity on NOX4 and NOX5, whose activation is independent of this subunit, although it suggests a more complex mode of action
Bratisl Med J 123(1):915
