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Oxygen radicals insert into the C-H bonds of PUFAs, generating lipid hydroperoxides and elevating levels of ROS, which induce ferroptosis (55)
The prediction model showed a benefit after 3 years, which is an estimated brain cholesterol turnover rate in adults, but most of the data in our cohort aggregates towards earlier follow-ups
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However, considering the complex roles of iron in immune functions and tissue repair, such therapies must be developed with caution to avoid the impairment of the essential reparative processes of the body
