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Mutations in the Rb pathway include deletions in CDKN2A , which encodes p16, and amplifications of CDK4

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Tepperman B.L., Whittle B.J

Additionally, inhibition of SLC1A5-mediated glutamine transport by knockdown of SLC1A5 or adding SLC1A5 inhibitor L--glutamyl-p-nitroanilide (GPNA) attenuates mTOR activation and proliferation of breast cancer cells, and these inhibitory effects are more prominent in TNBC tumor cells compared to luminal subtypes (88)

Cell targeting was enhanced by using PEGs of different molecular weights such as PAM2 with molecular weights of 2000 and 10,000, PAM4 with a molecular weight of 20,000, and PSH2 with a molecular weight of 2000