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Zhu H, Wang X, Meng X, Kong Y, Li Y, Yang C, et al
In this regard, HSV-1 infection of SHSY-5Y Neuroblastoma induce a 3-fold increase in levels of phosphorylated Tau, with GSK-3 responsible for the phosphorylation of Threonine-212 and Serine(s)-202, 396, and 404 in conjunction to PKA phosphorylation of Serine 214 (Wozniak et al., 2009)
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The installation and development of these diseases are closely linked to metabolic changes that generate a state of oxidative stress, due to the excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) [7,8]
