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Skin problems: High estrogen levels can cause skin issues such as acne and rosacea, affecting overall skin health

Typically, healthcare professionals recommend regular injections initially to correct a deficiency, followed by maintenance injections at longer intervals

In addition, there is a higher intensity of CD38 expression (measured by flow cytometry) in the more aggressive multi-hit variants, which allows further differentiation of the diseases and the use of CD38 as a biomarker for early diagnosis [14]

Maintenance doses are then tailored to keep those levels topped up, and their duration of effect is directly tied to the prescribed frequency (e.g., a shot every 12 weeks for many)