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ER phospholipid composition modulates lipogenesis during feeding and in obesity

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(70) confirmed that elevated LPS in PCOS mice can reach the ovaries and be recognized by macrophages, activating intracellular caspase-11 to initiate a cascade reaction of pyroptosis, leading to the cleavage of the pyroptosis execution protein Gasdermin D (GSDMD) into its active N-terminal fragment (GSDMD-N)