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Hoff PM, Eng C, Adinin RB, Wolff RA, Lin E, Kopetz S , Rodney A, Chang DZ, Abbruzzese JL

Expanding clinical applications beyond core GHD indications into metabolic syndrome, muscle-wasting conditions, and chronic kidney disease

The relationship of increases in these markers of oxidative damage to redox-modulated physiological responses of muscle to exercise is unclear as is the desirability of attempting to suppress these changes through the use of antioxidants

GLP-1RAs: Beyond glycemic control GLP-1RAs such as semaglutide and the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RAs tirzepatide enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through central pathways