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Such widespread protective effects have created strong incentives to develop new potent enhancers of NRF2 activity for the prevention and treatment of many diseases (several of which are presently incurable) in which both inflammatory and oxidative stress have a key pathogenic role

426,427 The causes of the initial senescence process include oncogenic signaling, genotoxic harm, extremely short telomeres, malfunctioning mitochondria, infections, oxidative stress, nutrient imbalances, and physical stress

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