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OLT1177 significantly alleviated brain edema after intracerebral hemorrhage in mice, maintained the integrity of the bloodbrain barrier, and reduced vascular leakage [165]

Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

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Eur J haematol (2000) 64(5):28191
