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The reduction of metabolic flexibility, mitochondrial dysfunction, and accumulation of ectopic lipids, particularly in the liver and adipose tissue, promote a state of inflammaging, which is further aggravated by the diminished amplitude and robustness of endogenous rhythms in both the SCN and peripheral metabolic organs (Cardinali and Hardeland, 2017

[DOI] [Google Scholar] 133.Baker W.L., Anglade M.W., Baker E.L., White C.M., Kluger J., Coleman C.I

If all symptomatic children with a B12 level below 500ng/L were treated without question and worried parents pleas for help listened to, this would go some way towards halting the untold suffering that families cope with every day
