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NAD+, short for nicotinamide adenine dinucleotide, is a coenzyme found in all living cells

Clin Endocrinol (Oxf) 81: 458466, 2014 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, Silecchia G, Leonetti F, Fraioli A, Picardi A, Morini S, and Cavallo MG

Furthermore, Mn preferentially accumulates in the mitochondria and causes mitochondrial dysfunction (Tinkov et al., 2021

2A), which is consistent with some earlier observations 50,51
