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Other approaches to establish organoids consist on culturing cell aggregates in suspension or by air-liquid-interface (ALI), another method where the basal cell layers grown in contact with the culture medium, while the external layers are exposed to the air allowing a higher oxygen supply than submerged organoid cultures [161]

It decreases VLDL synthesis and secretion by a) reducing hepatic lipogenesis (synthesis of FA from acetyl CoA), b) increasing beta-oxidation of FA and c) inhibiting TG-synthesizing enzymes (e.g., DGAT)

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MW, molecular weight in Dalton (Da), pKi values in nM