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"Unfortunately, metformin can reduce absorption of vitamin B12 and lead to a B12 deficiency and, subsequently, anemia

Abbreviations FA: fatty acid CPTI: carnitine palmitoyltransferase I FAO: fatty acid oxidation FAS: fatty acid synthesis CACT: carnitine acylcarnitine translocase mTORC1: mTOR complex 1 LOA: loss of attachment ROS: reactive oxygen species FDG: 2-deoxy-2-fluoro-D-glucose ACC1: acetyl-CoA carboxylase 1 ACC2: acetyl-CoA carboxylase 2 CoA: coenzyme A ARMS: alveolar rhabdomyosarcoma RXRs: retinoid X receptors PRL: prolactin HDAC1: histone deacetylase 1 ECs: endothelial cells References Hanahan D, Weinberg RA

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- It boosts energy levels from fat metabolism during physical activity