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PEGylation involves the covalent attachment of polyethylene glycol (PEG) chains to peptides, leveraging PEG's exceptional biocompatibility, hydrophilicity, and low immunogenicity

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[PubMed] Maquart FX, et al

In contrast, radiation promotes cuproptosis by increasing mitochondrial copper through upregulation of the copper importer solute carrier family 31 member 1 (SLC31A1, also known as CTR1) while simultaneously depleting mtGSH, thereby shifting copper homeostasis toward toxicity 170