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This regulatory effect aids in maintaining immune homeostasis in the lungs and mitigating inflammatory responses

The hope is that as the person increases their LDN dose that these storms will be less and less over time

This issue was partially addressed in the PARAGON-HF trial.44 The investigators found not only that hs-TnT was reduced by sacubitril/valsartan therapy compared with valsartan, but also that patients with a decrease in hs-TnT from randomisation to 16 weeks to a value to at or below the median value of 17 ng/l subsequently had lower risk of the composite outcome compared with those who had persistently elevated hs-TnT values.44 Further research will be required to determine whether therapies targeting the mechanism of hs-cTn elevation can improve symptom burden and clinical outcomes in the HFpEF population