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A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163

One of the most important compounds for carnitine is Vitamin C, as its synthesis involves different vitamin C-dependent enzymes and its deficiency has a very negative effect on L-carnitine synthesis in the body

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81 Another randomized placebo-controlled trial in 35 NAFLD patients did not find a beneficial effect of a mixture of eight probiotic strains of Lactobacillus , Bifidobacterium , and Streptococcus species, at a dose of 1.8 trillion CFU twice daily, on markers of cardiovascular or liver health after 10 weeks