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Tranexamic Acid for Upstream Melanin Production Inhibition: Tranexamic Acid blocks the signalling pathway that instructs melanin to be produced in response to UV and inflammatory stimuli, addressing pigmentation-driven dark circles at the production stage before melanin is synthesised

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While inhibition of xCT suppresses cystine uptake and induces ferroptosis, we identified -glutamylcyclotransferase (GGCT), a key enzyme in glutathione (GSH) degradation, as a metabolic compensation pathway that regenerates cysteine to sustain redox homeostasis