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This unique ability to hydrolyze O6-methyl-dGTP, highly conserved across evolution, is distinctive to MTH1 among human NUDIX enzymes ( To elucidate MTH1s recognition and hydrolysis mechanisms, researchers have resolved its crystal structure using X-ray crystallography (Svensson et al., 2011)

MMWR Morb Mortal Wkly Rep 64:155156 Besselink MG, van Santvoort HC, Buskens E et al (2008) Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

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