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COMT enzymes are also involved in metabolizing the female hormone estrogen and any gene alteration may cause estrogen dominance
Autophagy is controlled by several signalling pathways, including the PI3K/Akt/mTOR pathway, the AMPK pathway and the Beclin-1 complex

"The identity of glutathione S -transferase B with ligandin, a major binding protein of liver"

This favors the formation of 1 O 2