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Chronic hypoperfusion also leads to the observed trophic changes, including dermal atrophy, alopecia, and cool extremities

68 And, a first-in-human open-label interventional study in 10 neonates showed that intranasal delivery of bone marrow-derived MSCs was safe and had no adverse side effects

This is why a universal solution is seldom effective

They also didnt exhibit any kind of skin irritation or sensitivity in guinea pigs, and therefore, this can be used as a smart, topical antibacterial drug delivery system to treat skin inflammation and wound healing [183]
