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J Med Chem DOI:10.1021/acs.jmedchem.7b00389 [3]

While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

As mentioned, counteracted were neurons destruction in the substantia nigra (MPTP) [69], dopamine vesicle depletion (reserpine) [69], dopamine receptors blockade (neuroleptics) [68,70], dopamine over-release and re-uptake inhibition (amphetamine

Aim for at least 64 ounces of water daily, more if you are active or in a warm climate