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The antimalarial drugs and divicine, the active ingredient of fava beans, share the common property of exposing the cells of the body to oxidative stress, from the elevated production of reactive oxygen intermediates

The dual-pathway approach engages both the GHRH axis (upstream stimulation of GH synthesis and release) and the ghrelin axis (amplification of GH pulse amplitude) simultaneously, which published preclinical data suggests produces greater GH elevation than either compound alone

Clinical translation exploration: Validating the efficacy of combinations such as DRP-104 with immune checkpoint blockers in specific subgroups, for instance, KEAP1-mutant lung cancer (163)

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