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It plays crucial roles in oxygen binding and transport (globins), oxidative metabolism (cytochrome c oxidase, succinate dehydrogenase), xenobiotic detoxification (cytochrome P450), gas sensing (guanyl cyclases, nitic oxide synthase), and microRNA processing (DGCR8)
In addition, inhibitors that inhibit the expression and/or activity of SIRT1, SIRT3, and SIRT7 have also been shown to have renal protective effects
55 SakamotoK.YonokiY.KubotaY.KuwagataM.SaitoM.NakaharaT.et al (2006)
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