why are b12 injections better than pills vs. Oral Supplements: Which Is Better? Are B12 Shots Safe? Royal

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Medication Interactions Certain medications reduce the absorption of methylcobalamin, cyanocobalamin, and other B12 supplements, including: Proton pump inhibitors (omeprazole, esomeprazole, and lansoprazole) H2-receptor antagonists (cimetidine, famotidine, and ranitidine) Metformin Colchicine Cholestyramine Certain antibiotics (neomycin and chloramphenicol) If you use these or other medications, talk with a healthcare provider about ways to maintain healthy levels of B12.

However, researchers must account for potential variability in absorption

The peptide is not damaged, only the concentration changed