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Notably, the use of human THP-1 cells allowed us to evaluate also the contribution of NLRP3 inflammasome in treatment-induced responses, and this is of crucial importance given the inflammasome key role in immune reactions, its interaction with the complement pathway, and the fact that it can be activated by paclitaxel [8, 37, 38]

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Were more interested in body losses for people on the lower end of normal for total body stores, as theres no need to replenish excess amounts

Moreover, the reflux of menstrual blood into the ovaries and repeated local bleeding in ovarian lesions can create iron overload in the follicular fluid as well