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It is thus often associated with acne or inflammatory dermatoses or appears at sites of external injuries or dermatological procedures [25]. PIH commonly presents dark macules or patches at the site of the initial skin insult and more commonly affects individuals with darker skin tone

Increased ROS levels are thought to have an oncogenic effect, inducing DNA damage and chromosomal instability to activate proto-oncogenes and inactivate tumor suppressor genes (12, 13)

Emotional discomfort , including anxiety or grief, often disrupts the ability to relax at night

Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, et al