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Description
Based on preclinical studies, it has been suggested that L-carnitine supplementation could limit the imbalance between protein anabolism (synthesis) and catabolism (degradation) that leads to skeletal muscle wasting (42)
According to the energy starvation hypothesis, which induces that insufficient ATP supply underlies the contractile dysfunction presenting in heart failure [34], it seems reasonable that L-C improves energy metabolism in cardiomyocytes, which may finally translate into mechanical efficiency and contribute to the improvement of clinical symptoms and cardiac function
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