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198 Also, toxicity is a common feature of epigenetic drugs, which restricts the dose and time they can be administered
For example, breast cancer cell lines had a high capacity to reach the oxidized form of VIC due to overexpression of SVCT2 genes, associated also with a higher resistance to oxidative stress
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Being strongly affected in FRDA, the former two cell types prioritizes their studyalthough acquisition of these cells from patients are invasive (cardiac tissue) or inaccessible (neurons)
