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Moreover, OCTN2 mediates the tissue distribution of carnitine, ensuring that these tissues receive sufficient carnitine to maintain their normal functions [164]

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Acyl-CoA metabolism and partitioning

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In the mitochondria, a rise in matrix calcium (Ca mito ) activates the F 1 F 0 ATPase (complex V of mitochondrial respiratory chain) 8 , and several Ca sensitive dehydrogenases (CaDH mito ), including pyruvate dehydrogenase (PDH), -ketoglutarate dehydrogenase and the NAD-linked isocitrate dehydrogenase (IDH3) 9

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