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13, 20, 26, 27, 48, 70, 71, 72 They are actively taken up into the brain 73 and can affect diverse physiological processes such as cell signaling, 71 neurotransmitter synthesis and release, 70 mitochondrial function, 20 lipid metabolism, 13, 74 immune function, 75 cellcell interactions 76 and gene expression

Furthermore, supplementation with LC has a positive impact on numerous essential pathways involved in pathological skeletal muscle loss, which might explain at least some of the anti-catabolic benefits and improvements in fatigue-related metrics seen in chronic illness people who received it (Montesano et al., 2015, Ringseis et al., 2013)

-oxidation and other oxidative metabolic processes improve

ELISA kits for measuring human TMAO, PCSK9, APOA4, and murine TMAO were obtained from Lptech (China) and used according to the manufacturers instructions