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[1] Around 2030% of East Asians carry the rs671 (ALDH2*2) allele on chromosome 12, which results in a less functional acetaldehyde dehydrogenase enzyme, responsible for the breakdown of acetaldehyde, and accounts for most incidents of alcohol flush reaction worldwide

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10.1002/jemt.21032 131 MarinovV.TzanevaM.Zhelyazkova-SavovaM.GanchevaS.Valcheva-KuzmanovaS

Nat Rev Drug Discov 12:866885 Harvey PD, McDonald S, Fu E, Reuteman-Fowler C (2025) Efficacy and safety of iclepertin (BI 425809) with adjunctive computerized cognitive training in patients with schizophrenia