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A full HLA match with a sibling or unrelated donor is recommended preferably before the age of 10 years
MOTS-c treatment significantly (i) improves physical performance in young, middle-age, and old mice, (ii) regulates skeletal muscle metabolism and gene expression, and (iii) enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner
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Obesity and metabolic disorders The loss of barrier integrity is closely associated with the onset of metabolic disorders, including obesity and type-II diabetes (T2D)
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