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Expression of D3 was increased in the PBMC of hypertensive individuals (Ricci et al., 1997) and treating rats with the D3 agonist 7-OH-DPAT enhanced kidney function, which was blocked by pretreatment with a D3 specific antagonist (U-99194A) but not with the D2-like antagonist sulpiride (Luippold et al., 1998)
