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The first goal is to exclude other medical conditions that can cause persistent tiredness

A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]

[DOI] [PubMed] [Google Scholar] 15.Sikiric P., Seiwerth S., Rucman R., Turkovic B., Brcic L., Sever M., Klicek R., Radic B., Drmic D., Ilic S., et al

Importantly, glucose metabolism and insulin sensitivity were either unchanged or slightly improved, contrasting with the diabetogenic effects of growth hormone