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Thanks to their expanded interface with the target protein, peptide PROTACs demonstrate superior potency, higher selectivity, and reduced toxicity compared to low molecular weight compounds, especially when targeting proteins lacking well-defined binding pockets (Kargbo, 2019)
There is one FDA-approved drug that contains CBD, called Epidiolex
doi: 10.3233/MNM-160065 19 GaldeanoC
