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The maximum approved dose produces the greatest weight loss in clinical trials but also the highest side effect incidence

Counting shed hairs provides another metric

Dosing Protocol Standard Research Protocol Dose: 300mcg per day subcutaneous Timing: Fasted ideally 3060 minutes before eating or exercise Injection site: Lower abdomen or thigh (standard subQ technique) Frequency: Daily, or 5 days on / 2 days off Cycle length: 812 weeks, then 46 week break Reconstitution AOD-9604 dissolves readily in bacteriostatic water (BAC water) no acetic acid required, unlike some hydrophobic peptides

The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year