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Capone S, Brown A, Hartnell F, Sorbo MD, Traboni C, Vassilev V, et al

By blocking NNMT, you're keeping visceral fat cells in a more reactive state even as overall caloric restriction continues

Most people notice the difference within hours, sometimes the same afternoon

Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated
