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Overall, we found that CAR T cells in post-infusion BM samples from LTR have high levels of mTOR signaling, high metabolic polyfunctionality, and an effector immunometabolic profile, and that the BM microenvironmental milieu of LTR may promote mTOR activity for improved anti-tumor activity
Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery
The first section of the overview examines retatrutide, a synthetic peptide studied for unimolecular activity at GLP-1, GIP, and glucagon receptors
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