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The use of broad-spectrum antibiotics is the easiest method to alter the gut microbiota and thereby regulate TMAO levels

Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders ( We are not aware of prior studies reporting low S-5-HT in hypothyroidism or CFS

EGCG (epigallocatechin gallate, a green tea polyphenol) disrupts the binding of HK2 to mitochondria, thereby impairing energy metabolism and inducing apoptosis (101)

Veterinary Parasitology, Regional Studies and Reports, 15, 100262