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Boosalis, S

The epoxygenase CYP enzymes metabolize arachidonic acid by olefin epoxidation, resulting in four regioisomeric epoxyeicosatrienoic acids (EETs): 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Herrera C, Pettiglio MA, Bartnikas TB
MSU crystals activate the Mitogen-activated protein kinase (MAPK)/NF-B and Janus kinase-1 (JAK-1) - signal transducers and activators of transcription1/3 (STAT1/3) signaling pathways in macrophages, inducing M1 macrophages polarization and releasing M1 macrophages-associated factors TNF, IL-1, and IL-6 (66, 70)
