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[PMC free article] [PubMed] [Google Scholar] 21.Fan B., Chong V., Chan S., Lim G., Lim K., Tan G., Mucheli S.S., Kuperan P., Ong K.H

This process, using glutamate (Glu), cysteine (Cys), and glycine (Gly) as raw materials, depends on glutamate cysteine ligase (GCL) and glutathione synthetase (GS) catalysis, present only in the cytoplasmic matrix [23]

Therefore, a comprehensive synthesis of available evidence is needed to clarify whether non-invasive routes provide efficacy comparable to intramuscular therapy

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