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30 Three of the four RCTs of B12 alone used oral B12 (1000 g per day) and one used i.m
They were randomly assigned in the ratio of 1:1:1 to once-weekly subcutaneous CagriSema (n=31), semaglutide (n=31), or cagrilintide (n=30) (all escalated to 24 mg)
Furthermore, PTH and its derivatives increase SETDB1 expression to inhibit the expression of the peroxisome proliferator-activated receptor gamma gene through the NLK pathway within the MAPK signaling cascade, thereby suppressing the adipogenic differentiation of MSCs [173, 174]
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