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Description
PMC 1201730

Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth

This may be caused by direct blood vessel compression, as well as increased spinal cord tension, which may not only cause stretching of nerve fibers but also flattening of blood vessels

Benzbromarone has been linked to potential hepatic toxicity and cardiovascular risk, whereas probenecid may exhibit significant central nervous system toxicity and hypersensitivity syndrome, particularly when administered at higher dosages
