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Aggravating the above mentioned challenges, the classic treatments for T2DM (sulfonylurea [SU] and insulin) are associated with clinically relevant weight increases
Genetic predispositions can provide context for expected response patterns
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A subsequent larger study found that a lower dose (250 mg twice daily) taken for 3 months was as effective as 500 mg twice daily, with benefits emerging after the first 4 weeks [67]
