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Notably, cotadutide also alleviated fibrosis to a greater extent than liraglutide or obeticholic acid, despite dose adjustment to achieve similar weight loss in two preclinical mouse models of NASH
CBF, Cerebral Blood Flow
Heart rate as a risk factor for cardiovascular disease
This approach aims to attenuate these responses and leverage a potential metabolic advantage (higher energy expenditure), particularly in insulin-resistant states, while helping to recalibrate the homeostasis of the brains hungersatiety circuits
