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When deciding which of these GLP-1 receptor agonist medications is best for a patient, we discuss other factors like whether theyll struggle with daily injections (favoring semaglutide) or are prone to gastrointestinal symptoms (favoring liraglutide), Watson says

(Bifidobacterium lactis BS01, Bifidobacterium breve BR03, Lactobacillus acidophilus LA02, Lactobacillus plantarum LP09, Lactobacillus rhamnosus LR06, Lactobacillus casei LC03, Bifidobacterium bifidum BB01, Streptococcus thermophilus YO8, Lactobacillus plantarum LP01, Lactobacillus rhamnosus LR05, Lactobacillus rhamnosus GG, Bifidobacterium longum BL03, Lactobacillus reuteri LRE02, Lactobacillus salivarius subsp. salivarius CRL1328, Bifidobacterium lactis BA05)

These effects appear to be mediated through modulation of dopamine signaling in the mesolimbic reward system in animal models, potentially dampening the reinforcing properties of addictive substances

Specifically, systemic administration of exendin-4 (0.1 and 0.2 g/kg, i.p.) significantly attenuated the reinstatement of drug-seeking behavior elicited by both a priming injection of cocaine and re-exposure to conditioned cues previously paired with cocaine taking [121]