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Reduced calorie intake Significant weight loss Recent clinical studies have shown that some GLP-1 agonists can lead to 1015% body weight reduction, which is remarkable compared to older therapies

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For sarcopenia and age-related muscle dysfunction, GLP-1 RAs preserve muscle health through prevention of catabolic muscle protein breakdown, enhanced insulin and amino acid-stimulated muscle protein synthesis through improved mTOR pathway activation, reduced skeletal muscle inflammation and fibrosis, and enhanced mitochondrial biogenesis improving muscle metabolic efficiency [169,170,171,172]