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Principais benefcios : - Reduo significativa do peso corporal em estudos clnicos, com resultados de alto impacto na obesidade

doi: 10.2337/dc08-1355 35 GarberAHenryRRatnerRGarcia-HernandezPARodriguez-PattziHOlvera-AlvarezIet al

The gastrointestinal side effects commonly associated with tirzepatideincluding nausea, diarrhea, vomiting, and abdominal discomfortmay overlap with symptoms of celiac disease, particularly in patients with incomplete mucosal healing or inadvertent gluten exposure

[27] demonstrated that addition of alcohol to submaximal cholecystokinine stimulation of acinar cells mimics supramaximal cholecystokinine-induced apical blockade and redirects exocytosis to ectopic sites on the basolateral plasma membrane via protein kinase C-mediated activation of the Munc18c protein leading to pancreatitis