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When cortisol stays elevated, it can interfere with the SCFA-driven signals and the circadian timing that normally support healthy GLP-1 activity, which may leave appetite harder to regulate

Samajdar SS, Bhaduri G, Ghoshal PK, Mukherjee S, Pal J, Chatterjee N, Joshi SR (2024) Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with type 2 diabetes

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Understanding GLP-1 Medications Before we compare the two, let's quickly recap what GLP-1 medications are